How to Administer GLP-1 Medications: Pen and Syringe Methods Explained

GLP-1 (glucagon-like peptide-1) receptor agonists are commonly prescribed to manage type 2 diabetes and support weight loss. These medications are administered via subcutaneous injection, either through a prefilled pen or a syringe and vial. Below is a step-by-step guide to help you safely and confidently administer your GLP-1 medication at home.

Method 1: Using a Prefilled Injection Pen

1. Prepare the Injection Site

• Choose your site: Suitable locations include the abdomen (away from the belly button), upper thigh, or back of the upper arm.

• Clean the area: Use an alcohol wipe and let it dry completely.

2. Prepare the Pen

• Inspect the medication: Ensure it's clear and free of particles or discoloration.

• Attach a new needle as per the instructions.

• Prime the pen if needed. Dial a small dose and press to expel a drop of medication.

3. Set the Dose

• Dial in your prescribed dose.

4. Inject the Medication

• Pinch the skin and insert the needle at a 45°–90° angle.

• Press the injection button and hold for 5–10 seconds to ensure full delivery.

• Remove the needle and dispose of it in a sharps container.

5. After the Injection

• Apply gentle pressure with a cotton ball if needed.

• Store the medication as directed, typically refrigerated before opening.
  
  

Method 2: Using a Syringe and Vial

This method is more manual and requires extra attention to dose accuracy.

1. Gather Supplies

• GLP-1 vial or cartridge

• 1 mL insulin syringe

• Alcohol wipes, cotton ball, and sharps container

2. Prepare the Injection Site

• Wash your hands thoroughly.

• Clean your selected site (abdomen, thigh, or upper arm) with an alcohol swab.

3. Prepare the Medication

• Inspect the vial: Ensure it's clear and uncontaminated.

• Clean the vial’s rubber top with an alcohol swab and let it dry.

4. Draw the Dose

• Draw air into the syringe equal to your prescribed dose.

• Insert the needle into the vial, push in the air, then draw out the medication.

• Remove air bubbles by tapping the syringe and adjusting the plunger.

5. Inject the Medication

• Pinch the skin and insert the needle at a 45° angle.

• Inject slowly and steadily.

• Withdraw the needle and apply light pressure if needed.

6. Dispose Safely

• Immediately place the syringe and needle into a sharps container.

• Never reuse needles or dispose of them in regular trash.

7. Store and Rotate

• Follow storage guidelines for opened vials.

• Rotate injection sites to prevent irritation or scarring.
  

 Final Tips & Safety Reminders

• Stick to your dosing schedule—typically once weekly. If you miss a dose, follow your provider’s guidance.

• Watch for side effects, such as nausea or irritation at the injection site.

• Never reuse needles, and always dispose of them in a proper sharps container.

• Contact us with any concerns or side effects you’re unsure about.

Administering GLP-1 medications may feel intimidating at first, but with practice and care, it becomes part of a manageable routine!